| Business | Location | Product/Service | Employees |
| Virginia Department of Corrections | Sussex | Prison | 855 |
| Murphy Brown | Waverly | Pork | 500 |
| Sussex County School Board | Sussex | Education | 262 |
| Davis Oil | Stony Creek | Oil | 125 |
| Sussex County Government | Sussex | Government | 100 |
| Virginia Diner | Wakefield | Food/Catalog Sales | 93 |
| Airfield | Sussex | Youth Development | 41 |
| Hardee's | Waverly | Fast Food | 27 |
| McDonald's | Waverly | Fast Food | 27 |
| Isle of Wight Products |
Wakefield | Lumber | 20 |
